Han Zhao

This study investigates how SMC complexes interact during mitosis to shape 3D genome structure by engineering cohesin/condensin configurations on mitotic chromosomes.

This study identifies biallelic MAD2L1BP variants causing oocyte maturation arrest in female infertility and shows functional rescue with full-length cRNAs.

The paper profiles poly(A) tail dynamics in human oocytes and embryos, revealing dynamic changes in length and non-A residues, and identifies mechanisms for their regulation.

This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.

This study shows that gene conversion and NHEJ are major DNA repair mechanisms in human embryos, with gene conversion potentially useful for gene correction but also causing extensive loss of heterozygosity.