Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson's disease
Maria Otero‐Jimenez, Marcelina J. Wojewska, Simona Jogaudaite, David E. Miller, Sandra Gray‐Rodriguez, Gráinne Geoghegan, Laura Esther Abelleira, Tim J. Viney, Barbara Sárkány, Djordje O. Gveric, Steve Gentleman, Javier Alegre‐Abarrategui
The paper introduces an in situ seeding immunodetection assay to visualize alpha-synuclein and tau seeding activities with high spatial resolution in intact tissues, revealing neuron-driven alpha-synuclein seeding in Parkinson's disease before clinical symptoms.
npj Parkinson s Disease · Aug 25, 2025Peer-reviewedNeuroscience