Javier Alegre‐Abarrategui

This paper creates a humanised GBA-L444P mouse model to study GBA1 mutations in Parkinson's, finding gain-of-function effects on dopamine release and loss-of-function effects on alpha-synuclein pathology.

This study shows that temporal interference stimulation enhances neural progenitor cell maturation in vitro and promotes hippocampal neurogenesis in a mouse Alzheimer's model.

The paper introduces an in situ seeding immunodetection assay to visualize alpha-synuclein and tau seeding activities with high spatial resolution in intact tissues, revealing neuron-driven alpha-synuclein seeding in Parkinson's disease before clinical symptoms.

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.

The paper constructs a single-cell atlas of the Substantia nigra and identifies cell-specific gene expression patterns linked to Parkinson's disease and neuropsychiatric disorders.