Robust Colonization of Nasal Microbiota Across the Respiratory Tract and the Gut Modulates Innate Immune Response in a Germ-Free Pig Model
Shaurav Bhattarai, Tirth Uprety, Linto Antony, Chithra C. Sreenivasan, Sudeep Ghimire, Milton Thomas, David H. Francis, Steven R. Lawson, Feng Li, Joy Scaria, Radhey Shyam Kaushik
This study investigates how nasal microbiota colonization in germ-free pigs affects immune responses and gut-lung axis interactions, showing antibiotic disruption of microbial diversity and immune gene expression.
bioRxiv · Oct 31, 2025 · PreprintMicrobiology