Author

David I. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Assay:imaging· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alexandros SigarasiD· 1 shared Arun Prasad ManoharaniD· 1 shared Avner Hershlag· 1 shared Iman HajirasoulihaiD· 1 shared JAMIE A. GRIFOiD· 1 shared Jonas E. MalmsteniD· 1 shared Josue Barnes· 1 shared Kathleen A. MilleriD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperDevelopmental Biology

Alexandros SigarasORCID

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2 papers

Recent·Most cited

Automatic Ploidy Prediction and Quality Assessment of Human Blastocyst Using Time-Lapse Imaging

Suraj Rajendran, Matthew Brendel, Josue Barnes, Qiansheng Zhan, Jonas E. Malmsten, Pantelis Zisimopoulos, Alexandros Sigaras, Kwabena Ofori-Atta, Marcos Meseguer, Kathleen A. Miller, David I. Hoffman, Zev Rosenwaks, Olivier Elemento, Nikica Zaninović, Iman Hajirasouliha

This paper develops BELA, a deep learning model for ploidy prediction in human blastocysts using time-lapse imaging, achieving an AUC of 0.76 on the Weill Cornell dataset.

Nature Communications · Sep 5, 2024Peer-reviewedDevelopmental Biology

Evaluating genetic ancestry and self-reported ethnicity in the context of carrier screening

R. Shraga, Sarah Yarnall, Sonya Elango, Arun Prasad Manoharan, Sally Ann Rodriguez, Sara L. Bristow, Neha Kumar, Mohammad Niknazar, David I. Hoffman, Shahin Ghadir, Rita Vassena, Serena H. Chen, Avner Hershlag, JAMIE A. GRIFO, Óscar Puig

The paper evaluates the reliability of self-reported ethnicity versus genetic ancestry in carrier screening and finds discrepancies that affect carrier risk estimation.

BMC Genetics · Nov 27, 2017Peer-reviewedGenetics