Zev Rosenwaks

Modeling human embryonic adrenogenesis in pluripotentstem cell-derived corticomedullar-like assembloids

This study develops a method to model human adrenal development using pluripotent stem cell-derived assembloids that recapitulate corticomedullar differentiation and function.

Dysregulation of the actin cytoskeleton and FMRP causes polar body protrusion defects in human fragile X premutation and aged oocytes

Automatic Ploidy Prediction and Quality Assessment of Human Blastocyst Using Time-Lapse Imaging

This paper develops BELA, a deep learning model for ploidy prediction in human blastocysts using time-lapse imaging, achieving an AUC of 0.76 on the Weill Cornell dataset.

Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation

The paper investigates how maternal H3.3 contributes to paternal genome reprogramming and minor zygotic genome activation in mice.

Activation of the Maternal Genome Through Asymmetric Distribution of Oocyte-Genome-Associated Histone H3.3

This study identifies an asymmetric distribution of oocyte-specific H3.3 during early embryonic development, leading to differential maternal genome activation in blastomeres.

Robust Automated Assessment of Human Blastocyst Quality using Deep Learning

This paper develops an AI system to assess human blastocyst quality using deep learning, achieving 98% accuracy and identifying clinical factors affecting pregnancy rates.

Tripolar mitosis drives the association between maternal genotypes of PLK4 and aneuploidy in human preimplantation embryos

The paper identifies tripolar mitosis as a mechanism causing aneuploidy in human embryos and links it to maternal PLK4 genetic variants.