Cap-adjacent 2'-O-ribose methylation of RNA in C. elegans is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1
Eileen Clemens, Sarah Brivio, Mohammed Al-Khafaji, Peter Eijlers, Maheshika Kurukulasuriya, Irmgard U. Haussmann, David MacLeod, Marius A. Wenzel, Berndt Müller, Matthias Soller, Jonathan Pettitt
The paper investigates the role of cap-adjacent 2'-O-ribose methylation (cOMe) in C. elegans, showing it protects transcripts from decapping exonuclease EOL-1 and is essential for growth and germline development.
Nucleic Acids Research · Apr 8, 2026Peer-reviewedMolecular Biology