Systematic Elucidation and Validation of OncoProtein-Centric Molecular Interaction Maps
Joshua Broyde, David R. Simpson, Diana Murray, Evan Paull, Brennan Chu, Somnath Tagore, Sunny J. Jones, Aaron Timothy Griffin, Federico Manuel Giorgi, Alexander Lachmann, Peter K. Jackson, Alejandro Sweet-Cordero, Barry H. Honig, Andrea Califano
The paper introduces an algorithm to reconstruct context-specific molecular interaction maps centered on oncoproteins, validating it with KRAS in lung adenocarcinoma and identifying novel synthetic lethal proteins.
Nature Biotechnology · Sep 14, 2020Peer-reviewedSystems Biology