Aaron Timothy Griffin

Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations

The paper identifies master regulator dependencies in coexisting diffuse midline glioma subpopulations and shows that combination therapy targeting these regulators improves survival in vivo.

Identification and Pharmacological Targeting of Treatment-Resistant, Stem-like Breast Cancer Cells for Combination Therapy

The paper identifies treatment-resistant Cancer Stem-Like Cells in breast cancer using single-cell RNA sequencing and validates a drug combination to target them effectively.

An Information Theoretic Framework for Protein Activity Measurement

The paper introduces NaRnEA, a gene set analysis method that improves differential activity measurement of transcriptional regulatory proteins across cancer cohorts.

Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis

The paper uses phosphoproteomic time-series data and the VESPA algorithm to analyze drug resistance mechanisms in colon cancer cells, revealing adaptive signaling rewiring confirmed by CRISPRko assays.

Integrative Analysis of Checkpoint Blockade Response in Advanced Non-Small Cell Lung Cancer

This study identifies molecular and immune features associated with response to anti-PD-(L)1 therapy in NSCLC using a cohort of 393 patients.

Systematic Elucidation and Validation of OncoProtein-Centric Molecular Interaction Maps

The paper introduces an algorithm to reconstruct context-specific molecular interaction maps centered on oncoproteins, validating it with KRAS in lung adenocarcinoma and identifying novel synthetic lethal proteins.