Peter K. Jackson

This study identifies FAM53C as a regulator of the G1/S cell cycle transition, showing it interacts with DYRK1A and affects cell cycle progression in cultured cells and organoids.

The paper uses Metabolic STAMP to map GPCR signaling pathways in β-cells, revealing distinct kinase programs and phospho-signatures that modulate insulin secretion.

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

This study identifies RSG1/CPLANE2 as a causative gene for human ciliopathy and shows its role in ciliary transition zone assembly.

The paper develops STAMP to study temporal-spatial signaling in quiescence by synchronizing ciliogenesis and G0 transition with microscopy and phospho-proteomics, revealing transient phosphorylations in cellular functions.

The paper identifies ZMAT3 and CDKN1A as key hubs in the p53 tumor suppression network through integrative multiomic analyses in a mouse model.

The paper investigates how SARS-CoV-2 spike protein activates calcium and actin dynamics to enable filopodial extension and virus binding through ACE2.

The paper introduces an algorithm to reconstruct context-specific molecular interaction maps centered on oncoproteins, validating it with KRAS in lung adenocarcinoma and identifying novel synthetic lethal proteins.

The paper uses a CRISPR-based screen in 3T3-L1 cells to identify regulators of adipogenesis, finding that protein translation and stability mechanisms are critical for adipocyte expansion and lipogenesis.