Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire
Eric Engelbrecht, Oscar L. Rodriguez, William Lees, Zach Vanwinkle, Kaitlyn M. Shields, Steven Schultze, William S. Gibson, David R. Smith, Uddalok Jana, Swati Saha, Ayelet Peres, Gur Yaari, Melissa Laird Smith, Corey T. Watson
This study shows that genetic variations in immunoglobulin light chain loci influence the diversity of expressed light chain antibodies, affecting amino acid sequences and gene usage.
bioRxiv · May 28, 2025 · PreprintImmunology