Ayelet Peres

An integrated human immunoglobulin germline resource linking allele diversity to expressed repertoire structure

This paper constructs HUSA, a comprehensive germline resource linking allele diversity to expressed antibody repertoires by integrating long-read sequencing and AIRR-seq data.

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations

The paper identifies structural variants and coding polymorphisms in the human IGHC locus, revealing population-specific diversity and potential functional impacts.

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire

This study shows that genetic variations in immunoglobulin light chain loci influence the diversity of expressed light chain antibodies, affecting amino acid sequences and gene usage.

A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques

The paper develops methodologies to generate and analyze immunoglobulin loci variation in rhesus macaques, revealing extensive diversity and expanding existing allele sets by 60%.

An unbiased comparison of immunoglobulin sequence aligners

The paper introduces GenAIRR, a simulation framework for Ig sequences, and evaluates aligners to identify their performance characteristics, establishing a benchmarking standard for Ig sequence alignment.

AIRR-C Human IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes

The paper curates high-quality human immunoglobulin germline gene reference sets to improve AIRR-seq analysis accuracy and facilitate immunoglobulin gene studies.

Alternative splice variants and germline polymorphisms in human immunoglobulin light chain genes

The paper identifies 48 novel light chain variable gene polymorphisms in a Norwegian cohort and finds partial intron retention in alternative splice variants of low-expressed genes.

Mosaic deletion patterns of the human antibody heavy chain gene locus as revealed by Bayesian haplotyping

The paper develops a Bayesian haplotyping method to infer V-D-J haplotypes and deletion patterns in the human antibody heavy chain gene locus using antibody repertoire sequencing data.