William Lees

This paper constructs HUSA, a comprehensive germline resource linking allele diversity to expressed antibody repertoires by integrating long-read sequencing and AIRR-seq data.

The paper revises the standardization and validation pipeline for immune receptor data in the IEDB to improve data consistency and usability.

The paper identifies structural variants and coding polymorphisms in the human IGHC locus, revealing population-specific diversity and potential functional impacts.

This study shows that genetic variations in immunoglobulin light chain loci influence the diversity of expressed light chain antibodies, affecting amino acid sequences and gene usage.

The paper presents haplotype-resolved genomes of six ape species with high accuracy and provides comparative analyses to study evolutionary diversity and gene family evolution.

The paper develops methodologies to generate and analyze immunoglobulin loci variation in rhesus macaques, revealing extensive diversity and expanding existing allele sets by 60%.

The paper introduces a method using ultra-long sequencing and bioinformatics to resolve haplotypes in the human immunoglobulin heavy chain locus, uncovering novel alleles and structural variants.

The paper curates high-quality human immunoglobulin germline gene reference sets to improve AIRR-seq analysis accuracy and facilitate immunoglobulin gene studies.

This study identifies HVR-1 as an autoinhibitory region in HCV E1E2 that suppresses viral entry through conformational entropy, which is released upon receptor binding to enhance entry but reduce antibody resistance.