Uddalok Jana

This paper constructs HUSA, a comprehensive germline resource linking allele diversity to expressed antibody repertoires by integrating long-read sequencing and AIRR-seq data.

The paper identifies structural variants and coding polymorphisms in the human IGHC locus, revealing population-specific diversity and potential functional impacts.

This study shows that genetic variations in immunoglobulin light chain loci influence the diversity of expressed light chain antibodies, affecting amino acid sequences and gene usage.

The paper introduces a method using ultra-long sequencing and bioinformatics to resolve haplotypes in the human immunoglobulin heavy chain locus, uncovering novel alleles and structural variants.