APOE 4/4 promotes dysfunctional and inflammatory phenotypes concomitant with impaired maturation of hiPSC-derived astrocytes
Rebeca Vecino, Eva Díaz‐Guerra, Esther Arribas-González, David Sanz Gil, Francisco J. Fernández Acosta, Irene Serra, Elena P. Moreno‐Jiménez, Rosario Moratalla, Marta Navarrete, Carlos Vicario‐Abejón
This study shows that APOE 4/4 genotype leads to dysfunctional and inflammatory astrocytes with impaired maturation and altered glutamate/Aβ handling in hiPSC-derived cultures.
bioRxiv · Sep 10, 2026 · PreprintNeuroscience