Rosario Moratalla

APOE 4/4 promotes dysfunctional and inflammatory phenotypes concomitant with impaired maturation of hiPSC-derived astrocytes

This study shows that APOE 4/4 genotype leads to dysfunctional and inflammatory astrocytes with impaired maturation and altered glutamate/Aβ handling in hiPSC-derived cultures.

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors

This paper identifies distinct roles of dopamine D3 and D1 receptors in regulating motivation and reinforcement in the nucleus accumbens, showing compartmentalized signaling within the same cell type.

GBA1 mutations alter neuronal firing and structure, regulating VGLUT2 and CRYAB in dopamine neurons

This study shows that GBA1 mutations in dopamine neurons reduce VGLUT2 expression, increase firing rate, and cause structural changes linked to Parkinson's disease.

Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism.

The paper examines changes in serotonergic and dopaminergic neurons in the dorsal raphe nucleus of a Parkinson's disease mouse model following 6-OHDA injection.