Author

Francisco J. Fernández Acosta

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-6574-5594Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Alan Mackay‐SimiD· 1 shared Anne Maria KoivistoiD· 1 shared Anthony Robert WhiteiD· 1 shared Carlos Vicario‐AbejóniD· 1 shared David Sanz Gil· 1 shared Elena P. Moreno‐JiméneziD· 1 shared Elina PenttiläiD· 1 shared Emma KaartineniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Alan Mackay‐SimORCID

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2 papers

Recent·Most cited

APOE 4/4 promotes dysfunctional and inflammatory phenotypes concomitant with impaired maturation of hiPSC-derived astrocytes

Rebeca Vecino, Eva Díaz‐Guerra, Esther Arribas-González, David Sanz Gil, Francisco J. Fernández Acosta, Irene Serra, Elena P. Moreno‐Jiménez, Rosario Moratalla, Marta Navarrete, Carlos Vicario‐Abejón

This study shows that APOE 4/4 genotype leads to dysfunctional and inflammatory astrocytes with impaired maturation and altered glutamate/Aβ handling in hiPSC-derived cultures.

bioRxiv · Sep 10, 2026 · PreprintNeuroscience

Disease specific alterations in the olfactory mucosa of patients with Alzheimer's disease

Riikka Lampinen, Mohammad Feroze Fazaludeen, Simone Avesani, Tiit Örd, Elina Penttilä, Juha-Matti Lehtola, Toni Tapani Saari, Sanna Hannonen, Liudmila Saveleva, Emma Kaartinen, Francisco J. Fernández Acosta, Marcela Cruz-Haces, Heikki Löppönen, Alan Mackay‐Sim, Tarja Malm, , Katja M. Kanninen

This study identifies disease-specific gene expression and protein secretion patterns in olfactory mucosa cells from Alzheimer's patients, revealing potential diagnostic and mechanistic insights.

bioRxiv · Nov 24, 2020 · PreprintNeuroscience