Author

Elena P. Moreno‐Jiménez

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-9865-4875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Amber Penning· 1 shared Carlos Patricio FitzsimonsiD· 1 shared Carlos Vicario‐AbejóniD· 1 shared David Sanz Gil· 1 shared Dick Frans SwaabiD· 1 shared Dilara AyyildiziD· 1 shared Eleonora AronicaiD· 1 shared Erik NutmaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Amber Penning

Mutual co-authors in cluster

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2 papers

Recent·Most cited

APOE 4/4 promotes dysfunctional and inflammatory phenotypes concomitant with impaired maturation of hiPSC-derived astrocytes

Rebeca Vecino, Eva Díaz‐Guerra, Esther Arribas-González, David Sanz Gil, Francisco J. Fernández Acosta, Irene Serra, Elena P. Moreno‐Jiménez, Rosario Moratalla, Marta Navarrete, Carlos Vicario‐Abejón

This study shows that APOE 4/4 genotype leads to dysfunctional and inflammatory astrocytes with impaired maturation and altered glutamate/Aβ handling in hiPSC-derived cultures.

bioRxiv · Sep 10, 2026 · PreprintNeuroscience

Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer's disease, and cognitive resilience

Giorgia Tosoni, Dilara Ayyildiz, Sarah Snoeck, Elena P. Moreno‐Jiménez, Amber Penning, Estibaliz Santiago-Mujika, Olmo Ruiz Ormaechea, Hyunah Lee, Suresh Kumar Poovathingal, Kristofer Davie, Julien Bryois, Will Macnair, Jasper J. Anink, Luuk E. de Vries, Sahand Farmand, , Evgenia Salta

The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

Cell stem cell · Apr 24, 2026Peer-reviewedNeuroscience