TL1A overexpression in Crohn's Disease and mice alters Paneth cells and microbiota promoting ileal inflammation
Yuefang Ye, Shyam Kailashrao More, Hussein Hamade, Erica E. Alexeev, Yosuke Shimodaira, Anna Y. Blackwood, Dalton T. Stamps, Jordan H. Miller, Jay P. Abraham, Lisa S. Thomas, Sofi L. Castanon, Hannah Q. Estrada, Kotaro Kumagai, Alka A. Potdar, Talin Haritunians, , Kathrin S. Michelsen
This study shows that TL1A overexpression in Crohn's Disease and mice causes Paneth cell dysfunction and microbiota changes that promote ileal inflammation.
bioRxiv · Mar 2, 2025 · PreprintImmunology