Dermot P.B. McGovern

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study identifies 619 IBD risk signals, resolves 81 high-confidence variants, and prioritizes 664 candidate effector genes using GWAS, eQTL, and exome sequencing.

This study uses exome and genome sequencing to identify 68 genes directly associated with inflammatory bowel disease, providing clearer genetic insights and therapeutic targets.

The paper develops and evaluates a multiplexed PRM-MS assay for quantifying plasma proteins in an IBD cohort, demonstrating high quantifiability and consistent data acquisition.

The paper examines maternal IBD-related antibodies in cord blood and their associations with early life gut inflammation and microbiota composition.

This study shows that TL1A overexpression in Crohn's Disease and mice causes Paneth cell dysfunction and microbiota changes that promote ileal inflammation.

This paper introduces TEAQ, a software tool that selects clinical-grade biomarker candidates from DIA-MS data by evaluating protein quantification metrics in a discovery cohort.

The paper uses measured and predicted gene expression to identify ulcerative colitis patients at elevated risk of colectomy, showing both methods independently replicate in multiple datasets.

This study identifies shared and ethnicity-specific HLA associations with ulcerative colitis through trans-ethnic analysis of diverse populations.

The paper identifies 7 novel IBD-causing genes in Ashkenazi Jewish IBD patients using exome sequencing and analyzes their overlap with early-onset IBD and other diseases.

This study identifies HLA-DQA1*05 as a genetic risk factor for anti-drug antibody development in Crohn's disease patients treated with anti-TNF therapies.

The paper shows that IBD microbiotas alter gut CD4 T-cell balance and drive colitis in mice, with specific T-cell profiles predicting disease status and severity.