A unique lower X-gate in TASK channels traps inhibitors within the vestibule
Karin E. J. Rödström, Aytuğ K. Kiper, Wei Zhang, Susanne Rinné, Ashley C. W. Pike, Matthias Goldstein, Linus J. Conrad, Martina Delbeck, Michael G. Hahn, Heinrich Meier, Magdalena Platzk, Andrew Quigley, David Speedman, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, , Elisabeth P. Carpenter
This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.
bioRxiv · Jul 19, 2019 · PreprintMolecular Biology