Author

Leela Shrestha

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Organism:human· 1

Frequent Co-Authors

Ashley C. W. PikeiD· 2 shared Nicola A. Burgess-BrowniD· 2 shared Andrew QuigleyiD· 1 shared Aytuğ K. KiperiD· 1 shared David B. SaueriD· 1 shared David Speedman· 1 shared Eleanor WilliamsiD· 1 shared Elisabeth P. CarpenteriD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Ashley C. W. PikeORCID

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2 papers

Recent·Most cited

Structural Basis for Inhibition of Human Anion Transporter SLC26A6/PAT-1

Gamma Chi, Tina Bohstedt, Roslin Adamson, Ashley C. W. Pike, Leela Shrestha, Onur Cil, Marc O. Anderson, Maryam Izadiar, Eleanor Williams, Nicola A. Burgess-Brown, Jonathan M. Elkins, Katharina L. Duerr, David B. Sauer

This study reports cryo-EM structures of human PAT-1 with inhibitors to elucidate their inhibition mechanisms and domain interactions.

bioRxiv · Nov 3, 2026 · PreprintBiochemistry

A unique lower X-gate in TASK channels traps inhibitors within the vestibule

Karin E. J. Rödström, Aytuğ K. Kiper, Wei Zhang, Susanne Rinné, Ashley C. W. Pike, Matthias Goldstein, Linus J. Conrad, Martina Delbeck, Michael G. Hahn, Heinrich Meier, Magdalena Platzk, Andrew Quigley, David Speedman, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, , Elisabeth P. Carpenter

This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.

bioRxiv · Jul 19, 2019 · PreprintMolecular Biology