Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis
Astrid Cleven, Angelo D. Meringa, Péter Brázda, Domenico Fasci, Thijs Koorman, Tineke Aarts‐Riemens, Inez Johanna, Dennis X. Beringer, Patricia Hernández-López, Sabine Heijhuurs, Tomohiro Mizutani, Sangho Lim, Maarten A. Huismans, Jochem H. Bernink, David Vargas Diaz, , Zsolt Sebestyén
This study shows that single mutations during early oncogenesis can upregulate BTN2A1, enabling Vγ9Vδ2 TCR binding, but full activation requires subsequent phosphorylation of BTN3A1.
bioRxiv · Nov 19, 2024 · PreprintCancer Biology