Author

David W. Reid

Moderna Therapeutics (United States)Primary ORCID profile (0000-0001-9517-8212 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

David W. ReidiD1 paper · QIMR Berghofer Medical Research Institute

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Iain J. McFadyeniD· 2 shared Vladimir PresnyakiD· 2 shared B. Joseph Cabral· 1 shared Ban WangiD· 1 shared Brooke A. Goodman· 1 shared David Mauger· 1 shared David MorrisiD· 1 shared Georg SeeligiD· 1 shared

Activity by Year

2019-2019 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Iain J. McFadyenORCID

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2 papers

Recent·Most cited

mRNA structure regulates protein expression through changes in functional half-life

David Mauger, B. Joseph Cabral, Vladimir Presnyak, Stephen V. Su, David W. Reid, Brooke A. Goodman, Kristian H. Link, Nikhil Khatwani, John Reynders, Melissa J. Moore, Iain J. McFadyen

The paper shows that mRNA secondary structure affects protein expression by altering functional mRNA half-life, independent of codon usage.

Proceedings of the National Academy of Sciences · Nov 11, 2019Peer-reviewedMolecular Biology

Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

Paul J. Sample, Ban Wang, David W. Reid, Vladimir Presnyak, Iain J. McFadyen, David Morris, Georg Seelig

The paper develops a model to predict the effect of 5' UTR variants on translation using experimental data and deep learning, showing its application to disease-associated SNVs.

Nature Biotechnology · Jul 1, 2019Peer-reviewedSynthetic Biology