Melissa J. Moore

The paper shows that mRNA decay during T cell activation occurs through translation-dependent and independent pathways, with ribosome density determining the pathway used.

The paper uses EJC RIPiT-Seq to quantify pre-translational mRNPs and reveals higher flux through AS-NMD pathways than RNA-Seq captures.

The paper shows that mRNA secondary structure affects protein expression by altering functional mRNA half-life, independent of codon usage.

DEBrowser provides an interactive tool for differential expression analysis of count data without programming skills, demonstrating its capabilities on published datasets.

This study develops a method to probe mRNA 3D structures and finds that pre-translational mRNPs form linear rod-like structures without strong end interactions.

This study introduces spliceosome profiling to map intron excision sites with high resolution, revealing new introns and correcting misannotations in S. pombe.