Paul J. Sample

This paper designs a transgene that enhances CAR T cell persistence and tumor regression by integrating multiple engineered technologies in solid tumor models.

This paper designs a dynamically regulated IL-2 variant that enhances tumor-specific immune responses while reducing systemic toxicity.

The paper develops a model to predict the effect of 5' UTR variants on translation using experimental data and deep learning, showing its application to disease-associated SNVs.

The paper introduces SPLiT-seq, a scalable scRNA-seq method, and applies it to analyze 109,069 cells from a mouse brain, identifying 13 main cell populations and developmental substructures.