Author

Iain J. McFadyen

Moderna Therapeutics (United States)ORCID 0000-0002-7931-8008Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

David W. Reid· 2 shared Vladimir PresnyakiD· 2 shared B. Joseph Cabral· 1 shared Ban WangiD· 1 shared Brooke A. Goodman· 1 shared David Mauger· 1 shared David MorrisiD· 1 shared Georg SeeligiD· 1 shared

Activity by Year

2019-2019 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

David W. Reid

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2 papers

Recent·Most cited

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedNov 11, 2019

mRNA structure regulates protein expression through changes in functional half-life

David Mauger, B. Joseph Cabral, Vladimir Presnyak…·Iain J. McFadyen

The paper shows that mRNA secondary structure affects protein expression by altering functional mRNA half-life, independent of codon usage.

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multiomeexperimental assay

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Synthetic BiologyNature BiotechnologyPeer-reviewedJul 1, 2019

Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

Paul J. Sample, Ban Wang, David W. Reid…·Georg Seelig

The paper develops a model to predict the effect of 5' UTR variants on translation using experimental data and deep learning, showing its application to disease-associated SNVs.

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humanproteomics

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