High-content screening identifies FDA-approved activators of mitophagy
Carlo Viscomi, Giacomo Giacchin, Valeria Balmaceda, Marta Giacomello, Andrea Eastes, Samantha Corrà, Lucía Fernández-Del-Rio, Nikole Scillitani, Davide Steffan, Marco Sandri, Erika Fernández-Vizarra, Orian S. Shirihai, Cristiane Benincá
The paper screens FDA-approved compounds to find mitophagy activators, identifying Meptazinol and Ponatinib as top candidates that increase mitolysosomes but do not rescue bioenergetic defects in mitochondrial diseases.
bioRxiv · Nov 10, 2026 · PreprintCell Biology