Author

Andrea Eastes

Mitokinin (United States)ORCID 0000-0002-9271-1891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Akash ModyiD· 1 shared Alban OrdureauiD· 1 shared Alex Laishu· 1 shared Amy Wang· 1 shared Chao Tai· 1 shared Chengzhong WangiD· 1 shared Cristiane BenincáiD· 1 shared Daniel de Roulet· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Akash ModyORCID

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2 papers

Recent·Most cited

Activation of the protective arm of renin-angiotensin system enhances mitochondrial turnover improving respiration and decreasing integrated stress response in a human Complex III deficiency model.

Lucía Fernández-del-Río, Andrea Eastes, David Rincon Fernandez Pacheco, Nikole Scillitani, Jasmine Garza, Matthew Dugan, Matheus Oliveira, Pradnya Kadam, Iman Gauhar, Karel Erion, Kathleen E. Rodgers, Kevin J. Gaffney, Amy Wang, Marc Liesa, Cristiane Benincá, Orian S. Shirihai

This paper shows that activating the MasR receptor with CAP-1902 improves mitochondrial function in a human Complex III deficiency model by enhancing turnover and reducing stress.

bioRxiv · Mar 25, 2026 · PreprintCell Biology

Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models

R Chin, Rishi Rakhit, Dara Ditsworth, Chengzhong Wang, Johan Bartholoméüs, Song Liu, Akash Mody, Alex Laishu, Andrea Eastes, Chao Tai, Roy Y. Kim, Jessica Li, Steven Hansberry, Saurabh Khasnavis, Victoria A. Rafalski, , Nicholas T. Hertz

This study identifies MTK458, a PINK1 activator, which reduces α-synuclein pathology and pUb levels in Parkinson's disease models and correlates plasma pUb with disease progression.

bioRxiv · Feb 14, 2023 · PreprintNeuroscience