Marco Sandri

The paper screens FDA-approved compounds to find mitophagy activators, identifying Meptazinol and Ponatinib as top candidates that increase mitolysosomes but do not rescue bioenergetic defects in mitochondrial diseases.

This study shows that disrupting peroxisomal-mitochondrial interactions in skeletal muscle accelerates muscle dysfunction and age-related degeneration.

This study shows Hippo-YAP1/TAZ-TEAD signaling coordinates myoblast fusion and sarcomere assembly in skeletal muscle development through transcriptional regulation.

This study shows that niacin replenishes NAD+ levels, improves mitochondrial function, and reduces cachexia in cancer models and patients.

This study shows polyglutamine-expanded androgen receptor disrupts muscle function by altering calcium dynamics and excitation-contraction coupling gene expression, which can be reversed by treatment.