Dual inhibition of the nonsense mediated mRNA decay enhances tumour immunogenicity, drives immunoediting, and potentiates checkpoint blockade
Ivan Zadra, Davor Orsolic, Dimitri Kounis, Mario Acera Mateos, Guillermo Palou Márquez, Etna Abad, Laura Ortet, Anna Benito, Yacine Kharraz, Carlos Manuel Martínez, Elisabetta Mereu, Fran Supek, Ana Janic
This study shows that inhibiting nonsense-mediated mRNA decay enhances tumour immunogenicity, drives immunoediting, and improves checkpoint blockade efficacy in preclinical models.
bioRxiv · Dec 8, 2025 · PreprintCancer Biology