Nuclear adenosine metabolism defines a metabolic vulnerability unmasked by TP53 loss
Julia Urgel-Solas, Anna Benito, Laura Ortet, Savvas Kourtis, Etna Abad, Albert Coll‐Manzano, Anna Shevzov-Zebrun, Camilla Reiter Elbæk, CA Martinez, Matthew G. Vander Heiden, Sara Sdelci, Ana Janic
The paper identifies a metabolic vulnerability in TP53-deficient cells linked to nuclear adenosine metabolism and histone methylation, showing its role in DNA damage response and tumor growth.
bioRxiv · Jul 7, 2026 · PreprintCancer Biology