Author

Laura Ortet

Universitat Pompeu FabraORCID 0000-0002-3774-1844Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Ana JaniciD· 2 shared Anna Benito· 2 shared Etna AbadiD· 2 shared Albert Coll‐Manzano· 1 shared Anna Shevzov-Zebrun· 1 shared CA Martinez· 1 shared Camilla Reiter ElbækiD· 1 shared Carlos Manuel MartíneziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Ana JanicORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Nuclear adenosine metabolism defines a metabolic vulnerability unmasked by TP53 loss

Julia Urgel-Solas, Anna Benito, Laura Ortet, Savvas Kourtis, Etna Abad, Albert Coll‐Manzano, Anna Shevzov-Zebrun, Camilla Reiter Elbæk, CA Martinez, Matthew G. Vander Heiden, Sara Sdelci, Ana Janic

The paper identifies a metabolic vulnerability in TP53-deficient cells linked to nuclear adenosine metabolism and histone methylation, showing its role in DNA damage response and tumor growth.

bioRxiv · Jul 7, 2026 · PreprintCancer Biology

Dual inhibition of the nonsense mediated mRNA decay enhances tumour immunogenicity, drives immunoediting, and potentiates checkpoint blockade

Ivan Zadra, Davor Orsolic, Dimitri Kounis, Mario Acera Mateos, Guillermo Palou Márquez, Etna Abad, Laura Ortet, Anna Benito, Yacine Kharraz, Carlos Manuel Martínez, Elisabetta Mereu, Fran Supek, Ana Janic

This study shows that inhibiting nonsense-mediated mRNA decay enhances tumour immunogenicity, drives immunoediting, and improves checkpoint blockade efficacy in preclinical models.

bioRxiv · Dec 8, 2025 · PreprintCancer Biology