Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin
Miguel Martín‐Pérez, Anthony S. Grillo, Takashi K. Ito, Anthony S. Valente, Jeehae Han, Samuel W. Entwisle, Heather Z Huang, Dayae Kim, Masanao Yajima, Matt R. Kaeberlein, Judit Villén
The paper identifies PKC as a therapeutic target for treating mitochondrial disease by analyzing proteomic and phosphoproteomic changes in a mouse model of Leigh syndrome.
Nature Metabolism · Dec 14, 2020Peer-reviewedNeuroscience