Author

Samuel W. Entwisle

Harvard UniversityORCID 0000-0001-8515-636XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Judit VilléniD· 2 shared Miguel Martín‐PéreziD· 2 shared Adı́lson GuilhermeiD· 1 shared Ah‐Ram KimiD· 1 shared Anthony S. GrilloiD· 1 shared Anthony S. Valente· 1 shared David A. GuertiniD· 1 shared David J. Pedersen· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Judit VillénORCID

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3 papers

Recent·Most cited

GeneticsNature CommunicationsPeer-reviewedJul 15, 2025

Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC)

Raghuvir Viswanatha, Samuel W. Entwisle, Yanhui Hu…·Norbert Perrimon

The paper introduces IntAC, a CRISPR screening method for Drosophila cells that improves accuracy by suppressing early Cas9 activity, leading to a more comprehensive list of fitness genes.

13 citations

DrosophilaCRISPR screen

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NeuroscienceNature MetabolismPeer-reviewedDec 14, 2020

Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin

Miguel Martín‐Pérez, Anthony S. Grillo, Takashi K. Ito…·Judit Villén

The paper identifies PKC as a therapeutic target for treating mitochondrial disease by analyzing proteomic and phosphoproteomic changes in a mouse model of Leigh syndrome.

45 citations

mouseproteomics

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Systems BiologybioRxivPreprintOct 17, 2018

Cold-Induced Thermogenesis Increases Acetylation on the Brown Fat Proteome and Metabolome

Samuel W. Entwisle, Joan Sánchez-Gurmaches, Robert Lawrence…·Judit Villén

The paper identifies proteomic and metabolic changes in brown fat tissue in response to cold exposure, highlighting increased acetylation and lipid synthesis.

3 citations

mouseproteomics

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