Genetically encoded nAChR upregulation is neuroprotective in female parkinsonian mice
Gauri Pandey, Roger C Garcia, Debanjana Das, Akilesh R Mohan, Cristobal Rodriguez, Donovan Pollock, Nethra Karthik, Sushmitha Nalluri, Tan Nguyen, Christopher Polo, Sara M. Zarate, Mendell Rimer, Rahul Srinivasan
This study shows that upregulation of β2* nAChRs in SNc DA neurons protects female parkinsonian mice from neurodegeneration without ligand activation.
Journal of Neuroscience · Apr 28, 2026Peer-reviewedNeuroscience