Rahul Srinivasan

Genetically encoded nAChR upregulation is neuroprotective in female parkinsonian mice

This study shows that upregulation of β2* nAChRs in SNc DA neurons protects female parkinsonian mice from neurodegeneration without ligand activation.

Mitochondrial DNA damage in substantia nigra parscompacta astrocytes exacerbates dopaminergic neuron lossin a 6-hydroxydopamine mouse model of parkinsonism

This study shows that mitochondrial DNA damage in SNc astrocytes worsens dopaminergic neuron loss in a Parkinson's disease mouse model.

Heterogeneous brain region-specific responses to astrocytic mitochondrial DNA damage in mice

This study shows brain-region-specific differences in astrocytic responses to mitochondrial DNA damage using a novel AAV-based tool in mice.

Optogenetic inhibition of light-captured alcohol-taking striatal engrams facilitates extinction and suppresses reinstatement

The paper inhibits striatal engrams involved in alcohol-taking behaviors to show reduced future alcohol-seeking and enhanced extinction.

The smoking cessation drug cytisine requires systemically circulating estrogen for sex-specific neuroprotection in female parkinsonian mice

This study shows that cytisine's neuroprotective effect in female Parkinsonian mice depends on systemic estrogen, with estrogen depletion reversing this protection.

Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum

This study shows aging reduces calreticulin in astrocytic endfeet and changes calcium signaling dynamics in the mouse dorsolateral striatum.

Extracellular S100B alters spontaneous Ca2+ fluxes in dopaminergic neurons via L-type voltage gated calcium channels: Implications for Parkinson's disease

This study shows that extracellular S100B increases calcium fluxes in dopaminergic neurons via L-type voltage-gated calcium channels, contributing to Parkinson's disease pathology.

In situ characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampus

The paper characterizes calcium fluxes in astrocytic mitochondria in mouse brain regions, revealing subcellular and regional differences and dependencies on ER stores and neurotransmitters.