Altered polyadenylation site usage in SERPINA1 3'UTR in response to cellular stress affects A1AT protein expression
F N U Jiamutai, Abigail Hatfield, Austin Herbert, Debarati Majumdar, Vijay Shankar, Lela Lackey
The paper shows that IL-6 induces altered polyadenylation in SERPINA1, increasing long 3UTR isoforms that repress A1AT protein expression during inflammation.
Scientific Reports · Jul 2, 2025Peer-reviewedMolecular Biology