Inducible gene switches with memory in human T cells for cellular immunotherapy
Deboki Chakravarti, Leidy D. Caraballo Galva, Benjamin H. Weinberg, Wilson W. Wong
This paper introduces gene circuits with memory to control gene expression in T cells, demonstrating regulation of CAR expression and T cell activity using an FDA-approved drug.
ACS Synthetic Biology · Jul 3, 2019Peer-reviewedSynthetic Biology