Benjamin H. Weinberg

This paper introduces CREATE, a genetic circuit platform that enables complex signal processing in mammalian cells through programmable transcription factors and site-specific recombination.

This paper introduces a modular recombinase-based gene circuit that enables sequential gene expression using two ligands and applies it to model multi-stage genetic changes.

The paper develops a mechanistic model of the BLADE platform to predict performance of 256 synthetic DNA recombination circuits, showing good agreement with experimental data and identifying factors affecting circuit performance.

The paper introduces a library of inducible split recombinases for precise and multiplexed gene expression control in mammalian cells and mice.

This paper introduces gene circuits with memory to control gene expression in T cells, demonstrating regulation of CAR expression and T cell activity using an FDA-approved drug.