UFMylation orchestrates chromatin engagement of core NHEJ components to promote DNA double-strand break repair
Zijuan Wang, Benjamin M. Foster, Isabelle Cristine da Costa, Yue Wu, Deepak Behera, Francesca Conte, Eleanor W. Trotter, Maria Jose Cabello-Lobato, Shweta Choudhary, Reuven Wiener, Petra Beli, Duncan L. Smith, William H. Banks, Steve Bagley, Shane A McKee, , Christine K. Schmidt
The paper identifies UFM1 as a regulator of NHEJ by orchestrating chromatin engagement of core components, linking UFMylation defects to DSB repair defects.
bioRxiv · Jun 16, 2025 · PreprintMolecular Biology