Author

Duncan L. Smith

University of ManchesterORCID 0000-0003-1518-5768Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Iain HaganiD· 2 shared Amanda K. ChapliniD· 1 shared Benjamin M. FosteriD· 1 shared Christine K. SchmidtiD· 1 shared Deepak Behera· 1 shared Eleanor W. TrotteriD· 1 shared Eve LeddyiD· 1 shared Francesca ConteiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Iain HaganORCID

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Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 21, 2026

Loss of T73T75 phosphorylation on PP2A-B56Par1 advances mitotic entry and reduces S. pombe cell size

Lenka Hálová, Yvonne Connolly, Duncan L. Smith…·Iain Hagan

The paper identifies that phosphorylation of T73T75 on PP2A-B56Par1 by CDK1-Cyclin B delays mitotic entry and increases cell size in S. pombe.

DOI 10.64898/2026.01.19.700315

yeastexperimental assay

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Cancer BiologybioRxivPreprintNov 12, 2025

Epigenetic silencing of transposable elements by IRF2BP2 is a selective dependency of myeloid leukemia

Jingru Xu, Jessica Whittle, Liam Clayfield…·Georges Lacaud

This study identifies IRF2BP2 as a critical regulator of transposable element silencing in AML, showing its loss leads to TE activation and leukemia cell death.

DOI 10.1101/2025.11.12.688028

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Molecular BiologybioRxivPreprintJun 16, 2025

UFMylation orchestrates chromatin engagement of core NHEJ components to promote DNA double-strand break repair

Zijuan Wang, Benjamin M. Foster, Isabelle Cristine da Costa…·Christine K. Schmidt

The paper identifies UFM1 as a regulator of NHEJ by orchestrating chromatin engagement of core components, linking UFMylation defects to DSB repair defects.

DOI 10.1101/2025.06.16.659844

humanexperimental assay

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