Petra Beli

This study shows that phosphorylation of Z granule components regulates germ granule organization and RNAi inheritance in C. elegans.

The paper shows that branching of polyubiquitin chains on PCNA, mediated by UBE2K, orchestrates the DNA replication stress response by promoting re-priming of stalled forks and requiring BRCA1-dependent repair.

This study identifies Myo6's role in DSB repair by interacting with KU70/80 and VCP, facilitated by F-actin, to extract the KU70/80 complex from chromatin.

This study profiles the human phosphoproteome in response to eleven DNA damage agents, identifying core phosphorylation sites and DDR signatures, and links proteasome regulation to the DDR via UBE3A.

The paper identifies MAEA as a critical regulator of DNA repair and replication, with loss of function causing developmental delay and neurodevelopmental deficits.

This study uses a ubiquitin replacement strategy to show K29-linked ubiquitylation regulates SUV39H1 stability and H3K9me3 levels in human cells.

The paper identifies RS splicing regulatory proteins as key regulators of light-dependent splicing and seedling development in Arabidopsis.

This study shows that ubiquitin activates SPRTN protease to degrade DNA-protein crosslinks, maintaining genome stability and preventing disease.

The paper identifies UFM1 as a regulator of NHEJ by orchestrating chromatin engagement of core components, linking UFMylation defects to DSB repair defects.

The paper investigates the repair of rNMP-derived nick lesions during DNA replication and identifies a genetic network essential for this process.

The paper identifies mutations in E3 ubiquitin ligases that restore development in SWI/SNF mutants in C. elegans, suggesting potential therapeutic targets for human developmental disorders.

The paper shows that redundancy among nuclear receptor bookmarking factors ensures robust reactivation of pluripotency genes after mitosis.

This study shows that Makorin1 promotes oskar translation by displacing Bruno from its 3' UTR, essential for embryonic patterning and germ cell formation in Drosophila.

This study identifies MKRN1 as a key player in ribosome-associated quality control by promoting ribosome stalling at poly(A) sequences to prevent erroneous protein production.

This study shows RAB18 regulates autophagy by linking lipid droplets to lipid supply, and ATG9A phosphorylation can partially restore autophagy when RAB18 is absent.