Amanda K. Chaplin

Characterisation of the conformational changes of GlnH that stimulate PknG activity in Mycobacteria and Corynebacterium glutamicum

The paper determines the structures of GlnH from different organisms to understand how conformational changes in response to aspartate trigger signaling via GlnX.

UFMylation orchestrates chromatin engagement of core NHEJ components to promote DNA double-strand break repair

The paper identifies UFM1 as a regulator of NHEJ by orchestrating chromatin engagement of core components, linking UFMylation defects to DSB repair defects.

DNA polymerase Lambda is anchored within the NHEJ synaptic complex via Ku70/80

This study identifies how DNA polymerase Lambda interacts with the NHEJ complex via Ku70/80, revealing the molecular basis for its recruitment and activity in DNA repair.

Targeting DNA-PK is a highly conserved poxvirus innate immune evasion mechanism

This study shows that DNA-PK is a conserved DNA sensor in chickens that poxviruses evade by targeting with OPG020/OPG031 proteins, highlighting its role in innate immunity beyond mammals.