HDAC6 inhibition as a mechanism to prevent axon degeneration in the mSOD1G93A mouse model of ALS.
Andrew J Phipps, Samuel Dwyer, Jessica Marie Collins, Fariha Kabir, Rachel A.K. Atkinson, Anisuzzaman Chowdhury, Lyzette Matthews, Deepika Dixit, R. S. TERRY, Jason A. Smith, Nuri Gueven, William R. Bennett, Anthony L Cook, Anna Elizabeth King, Sharn E. Perry
This study shows HDAC6 inhibition with ACY-738 stabilizes microtubules and reduces lower motor neuron degeneration in mSOD1G93A mice, but does not prevent motor function decline.
bioRxiv · Aug 28, 2023 · PreprintNeuroscience