HDAC6 inhibition as a mechanism to prevent axon degeneration in the mSOD1G93A mouse model of ALS.
Andrew J Phipps, Samuel Dwyer, Jessica Marie Collins…·Sharn E. Perry
This study shows HDAC6 inhibition with ACY-738 stabilizes microtubules and reduces lower motor neuron degeneration in mSOD1G93A mice, but does not prevent motor function decline.