Deepika Mokkachamy Chellapandi

TLR4-mediated neuroimmune signalling drives proprioceptive neuron degeneration in Friedreich ataxia

This study identifies TLR4-mediated neuroimmune signaling as a driver of proprioceptive neuron degeneration in Friedreich ataxia and shows that inhibiting TLR4 reduces disease progression.

Frataxin depletion leads to decreased soma size and activation of AMPK metabolic pathway in dorsal root ganglia sensory neurons

This study shows that frataxin depletion in DRG neurons causes reduced soma size and activates the AMPK metabolic pathway, with potential therapeutic implications using ALA.