Amélie Weiss

The paper develops an imaging and analysis framework to map human microglial activation states using handcrafted and deep learning features, showing deep learning features achieve high classification accuracy and correlate with biological states.

This study shows that frataxin depletion in DRG neurons causes reduced soma size and activates the AMPK metabolic pathway, with potential therapeutic implications using ALA.

The paper identifies compounds that restore morphology in Parkinson's disease neurons by targeting mitochondrial uncoupling.

The paper presents a comprehensive genetic perturbation dataset using Cell Painting to analyze gene expression effects in human cells, revealing novel gene clusters and functional relationships.

This study screens small molecules in SHANK3-deficient neuronal models to identify compounds that rescue developmental and synaptic defects in Phelan-McDermid syndrome.

This study uses machine learning to identify subcellular phenotypic changes in human dopaminergic neurons exposed to bisphenols and perfluoroalkyls, showing increased alpha-synuclein and decreased neurite length.

Cell Painting images and profiles for 115,796 compounds in U2OS cells from 12 laboratories; 15.2% of analyzed compounds are phenotypically active, and cross-laboratory replicates cut reference-compound activity by 34%.

The paper identifies miR-124 as a positive regulator of alphavirus infection through a genome-wide miRNA screen and shows its direct interaction with viral RNA.