A high-resolution blood immune cell doublet atlas via imaging spectral cytometry
Cheryl Kim, Denise Hinz, Aaron J. Middlebrook, Aaron J. Tyznik, Louise M. D’Cruz, Thomas J. Scriba, Bjoern Peters, Julie G. Burel
Image-based gating on an imaging spectral cytometer resolves 12 high-purity immune doublet types in human blood; in tuberculosis, doublet frequencies are unchanged but tightly contacting T cell-monocyte doublets increase.
bioRxiv · Sep 8, 2026 · PreprintImmunology✦ In-depth digest