Histone hyperacetylation-linked upregulation of KRAB zinc finger proteins impedes glial differentiation in Huntington's disease
Peter Brøgger, John N. Mariani, Dennis Salinas, Benjamin Mansky, Steven J. Schanz, Nguyen P.T. Huynh, Rossana Foti, Steven A. Goldman
The paper identifies histone hyperacetylation and KZFP overexpression in HD glial progenitor cells as mechanisms impairing glial differentiation.
bioRxiv · Dec 2, 2025 · PreprintNeuroscience